Grants
Sponsor: Rackham Graduate School, University of Michigan, Ann Arbor, MI
Role: Principal recipient
Title: Notch signaling is a critical regulator of allogeneic T cell responses mediating graft-versus-host disease.
Total project period: 03/2009-04/2009
Total direct costs: $600 (travel)
Aims and goals: Present my research on determining the mechanism of Notch action of alloreactive T cell differentiation during graft-versus-host disease at Cold Spring Harbor Gene Expression and Signaling in the Immune System Conference.
Sponsor: Rackham Graduate School, University of Michigan, Ann Arbor, MI
Role: Principal recipient
Title: Unraveling the mechanisms of Il2 and Ifng gene regulation in Notch-deprived alloreactive T cells.
Total project period: 10/2009-01/2010
Total direct costs: $1,500 (research)
Aims and goals: Examine if Notch signaling regulates the intensity of NFkB activation in primary alloreactive T cells, leading to enhanced Il2 and Ifng gene transcription.
Sponsor: Rackham Graduate School, University of Michigan, Ann Arbor, MI
Role: Principal recipient
Title: Notch signaling is a critical regulator of allogeneic T cell responses mediating graft-versus-host disease.
Total project period: 10/2010-11/2010
Total direct costs: $600 (travel)
Aims and goals: Present my research on investigate the signal transduction pathways downstream of the T cell receptor leading to cytokine secretion in Notch-deprived alloreactive CD4+ and CD8+ T cells at the Autumn Immunology Conference in Chicago, IL.
Sponsor: Rackham Graduate School, University of Michigan, Ann Arbor, MI
Role: Principal researcher
Title: The role of Notch signaling in regulating Foxp3 expression in alloreactive CD4+ T cells.
Total project period: 01/2011-04/2011
Total direct costs: $3,000 (research)
Aims and goals: Determine if Notch-deprived Tregs contribute to suppressed cytokine production by conventional Notch-deficient alloreactive T cells in vivo and in vitro.
Sponsor: Immunology Program Miller Fund, University of Michigan, Ann Arbor, MI
Role: Principal researcher
Title: The role of Notch signaling in the expansion of regulatory T cells and in cAMP production by alloreactive CD4+ and CD8+ T cells during graft-versus-host disease.
Total project period: 05/2011-05/2012
Total direct costs: $20,000 (research)
Aims and goals: Investigate whether Notch signaling promotes the de novo generation of Tregs in the
periphery after allogeneic bone marrow transplantation and if this results in increased cAMP levels in both alloreactive Treg and Tconv.
Sponsor: Rackham Graduate School, University of Michigan, Ann Arbor, MI
Role: Principal recipient
Title: Notch critically regulates CD4+ and CD8+ T cell responses after allogeneic bone marrow transplantation.
Total project period: 09/2011-10/2011
Total direct costs: $950 (travel)
Aims and goals: Present my research on investigating the signal transduction pathways in Notch-deficient T cells that lead to an anergic-like T cell phenotype during graft-versus-host disease at the Notch Meeting in Athens, Greece.
Sponsor: Rackham Graduate School, University of Michigan, Ann Arbor, MI
Role: Principal recipient
Title: Notch inhibition in alloreactive CD4+ and CD8+ T cells blocks graft-versus-host disease by inducing a hyporesponsive program with features of T cell anergy
Total project period: 12/2012
Total direct costs: $700
Aims and Goals: Present my research on investigating the signal transduction pathways in Notch-deficient T cells that lead to an anergic-like T cell phenotype during graft-versus-host disease at the American Society of Hematology Meeting, Atlanta, GA.
Role: Principal recipient
Title: Notch signaling is a critical regulator of allogeneic T cell responses mediating graft-versus-host disease.
Total project period: 03/2009-04/2009
Total direct costs: $600 (travel)
Aims and goals: Present my research on determining the mechanism of Notch action of alloreactive T cell differentiation during graft-versus-host disease at Cold Spring Harbor Gene Expression and Signaling in the Immune System Conference.
Sponsor: Rackham Graduate School, University of Michigan, Ann Arbor, MI
Role: Principal recipient
Title: Unraveling the mechanisms of Il2 and Ifng gene regulation in Notch-deprived alloreactive T cells.
Total project period: 10/2009-01/2010
Total direct costs: $1,500 (research)
Aims and goals: Examine if Notch signaling regulates the intensity of NFkB activation in primary alloreactive T cells, leading to enhanced Il2 and Ifng gene transcription.
Sponsor: Rackham Graduate School, University of Michigan, Ann Arbor, MI
Role: Principal recipient
Title: Notch signaling is a critical regulator of allogeneic T cell responses mediating graft-versus-host disease.
Total project period: 10/2010-11/2010
Total direct costs: $600 (travel)
Aims and goals: Present my research on investigate the signal transduction pathways downstream of the T cell receptor leading to cytokine secretion in Notch-deprived alloreactive CD4+ and CD8+ T cells at the Autumn Immunology Conference in Chicago, IL.
Sponsor: Rackham Graduate School, University of Michigan, Ann Arbor, MI
Role: Principal researcher
Title: The role of Notch signaling in regulating Foxp3 expression in alloreactive CD4+ T cells.
Total project period: 01/2011-04/2011
Total direct costs: $3,000 (research)
Aims and goals: Determine if Notch-deprived Tregs contribute to suppressed cytokine production by conventional Notch-deficient alloreactive T cells in vivo and in vitro.
Sponsor: Immunology Program Miller Fund, University of Michigan, Ann Arbor, MI
Role: Principal researcher
Title: The role of Notch signaling in the expansion of regulatory T cells and in cAMP production by alloreactive CD4+ and CD8+ T cells during graft-versus-host disease.
Total project period: 05/2011-05/2012
Total direct costs: $20,000 (research)
Aims and goals: Investigate whether Notch signaling promotes the de novo generation of Tregs in the
periphery after allogeneic bone marrow transplantation and if this results in increased cAMP levels in both alloreactive Treg and Tconv.
Sponsor: Rackham Graduate School, University of Michigan, Ann Arbor, MI
Role: Principal recipient
Title: Notch critically regulates CD4+ and CD8+ T cell responses after allogeneic bone marrow transplantation.
Total project period: 09/2011-10/2011
Total direct costs: $950 (travel)
Aims and goals: Present my research on investigating the signal transduction pathways in Notch-deficient T cells that lead to an anergic-like T cell phenotype during graft-versus-host disease at the Notch Meeting in Athens, Greece.
Sponsor: Rackham Graduate School, University of Michigan, Ann Arbor, MI
Role: Principal recipient
Title: Notch inhibition in alloreactive CD4+ and CD8+ T cells blocks graft-versus-host disease by inducing a hyporesponsive program with features of T cell anergy
Total project period: 12/2012
Total direct costs: $700
Aims and Goals: Present my research on investigating the signal transduction pathways in Notch-deficient T cells that lead to an anergic-like T cell phenotype during graft-versus-host disease at the American Society of Hematology Meeting, Atlanta, GA.
